THE PROPERTIES OF T ANTIGENS EXTRACTED FROM GROUP A HEMOLYTIC STREPTOCOCCI
نویسندگان
چکیده
منابع مشابه
The Properties of T Antigens Extracted from Group a Hemolytic Streptococci
1. T antigens of group A hemolytic streptococci have been obtained in soluble form by digestion of the bacterial cells with pepsin or trypsin. Large quantities of this antigen were readily extracted from type 1 strains, whereas only small amounts could be obtained from strains of other types. 2. The T antigen, prepared in this way from a type 1 strain, was partially purified by chemical precipi...
متن کاملThe Endotoxic Properties of Lysates of Group a Hemolytic Streptococci
Suspensions of group A streptococci were subjected to mechanical disruption by shaking with glass beads. The supernatant solutions produced severe delayed inflammatory reactions on intradermal injection into normal rabbits. Intravenous injections caused systemic reactions characterized by fever, leucopenia, and peripheral vasomotor phenomena. These effects were more pronounced in rabbits which ...
متن کاملType-specific Antigens, M and T, of Matt and Glossy Variants of Group a Hemolytic Streptococci
1. Two qualitatively different type-specific antigens, designated M and T, have been found present in matt variants of group A hemolytic streptococci, but only one of these, the T antigen, occurs in the degraded glossy variant. 2. The protein nature of the M antigen, present in matt variants only, has been demonstrated in previous work, but the chemical characteristics of the newly recognized a...
متن کاملTyping Group a Hemolytic Streptococci
Two methods of typing group A hemolytic streptococci have been described: slide agglutination and anti-M precipitin tests. The first, developed by Griffith (1), is more extensively used. I t has the distinct advantages of requiring small amounts of serum and culture, and of a quick reaction time when all conditions are favorable. I t has certain disadvantages: The granular growth of some strain...
متن کاملThe Significance of M and T Antigens in the Cross Reactions between Certain Types of Group a Hemolytic Streptococci
In any one strain the occurrence of the previously recognized type-specific protein, M, is usually completely correlated with the presence of the recently recognized type-specific antigen, T. Strain C203 is exceptional in having the T substance of type 1 as well as the two type-specific antigens, M and T, characteristic of type 3. It does not have the M antigen of type 1. While other strains wi...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1946
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.84.5.449